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This activation significantly increased the Bcl-2-associated X protein (Bax)/B-cell lymphoma 2 (Bcl-2) ratio and cysteine-aspartate protease 3 (Caspase-3) expression, inhibited GPX4 and quinone oxidoreductase 1 (NQO1) expression, increased MDA levels, and promoted apoptosis, ferroptosis, and lipid peroxidation in NSC-34 cells

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This work was supported in part by the Medical Science and Technology Project of Zhejiang Province (2024KY1788), Program of Taizhou Science and Technology Grant (23ywa33), Major Research Program of Taizhou Enze Medical Center Grant (19EZZDA2), Open Project Program of Key Laboratory of Minimally Invasive Techniques and Rapid Rehabilitation of Digestive System Tumors of Zhejiang Province (21SZDSYS01), and the National Natural Science Foundation of China (project number 61865014)

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