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PMID:9084458 Spicak V et al
361,362,363 Proton magnetic resonance spectroscopy studies have shown a reduced N-acetylaspartate to creatine ratio in the thalamus and parietal white matter pathways of DPN patients, indicating neuronal dysfunction
Maternal obesity is associated with a lipotoxic placental environment
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These effects can be especially problematic in patients being treated for mood disorders such as bipolar disorder or schizophrenia
To overcome these limitations, we propose that future strategies must prioritize lesion-focused drug delivery, such as nanocarriers and triggerable prodrugs, alongside biomarker-guided treatment regimens to decouple efficacy from systemic risk, paving a credible path for the clinical application of Erastin-class agents in EMS
