The Food and Drug Administration (FDA) Its not completely clear how semaglutide reduces these risks
Glutathione's detoxifying prowess helps eliminate harmful substances like PCBs, synthetic estrogens, and heavy metals from your skin, shielding you from the damaging effects of bacteria, viruses, pollutants, and free radicals
Participants were randomized 2:1 to 68 weeks of once-weekly subcutaneous semaglutide 2.4 mg or placebo, both alongside lifestyle intervention
A recent poll found that 12% of Americans about 1 in 8 adults have taken a GLP-1 medication
The study included participants up to age 75, and subgroup analyses showed comparable efficacy across age groups, although absolute weight loss was modestly lower in adults over 65
## Availability Status: March 2026 - **FDA status:** Phase 3 clinical trials ongoing - **Expected approval timeline:** Potentially 2026-2027 - **Brand availability:** None yet - **Current access:** Compounding pharmacies (503A/503B) with valid prescription For a detailed breakdown of [retatrutide's FDA approval status and projected timeline](/guides/retatrutide-fda-approval-2026-timeline-status), see our dedicated tracker the date brand pricing becomes available depends directly on when retatrutide clears FDA review