Blood sugar-lowering effects compound dangerously
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Patients with a history of severe hypoglycemia, hypoglycemia unawareness, or long-standing diabetes with autonomic neuropathy require particularly careful assessment
Pioglitazone , a thiazolidinedione, directly enhances insulin sensitivity in adipose tissue and muscle but carries risks of weight gain, fluid retention, and bone fractures
[81] [111] Biochemistry [edit] Coenzyme function [edit] Vitamin B 12 functions as a coenzyme, meaning that its presence is required in some enzyme-catalyzed reactions
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