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doi: 10.1016/j.jdermsci.2015.07.009 76 JohnstonAGudjonssonJEAphaleAGuzmanAMStollSWElderJT
Naltrexone-bupropion is described as an opioid antagonist paired with dopamine and norepinephrine reuptake inhibition, while off-label metformin is framed as working through insulin sensitivity and gut glucose absorption
Research shows that chronic inflammation accelerates cellular aging, increases the risk of cardiovascular disease, and contributes to metabolic dysfunction
10.1097/ju.0000000000004180 14 BromfieldE
"Health Canada New Drug Authorizations: 2015 Highlights"
A 2017 study found that B12 supports healthy sperm by increasing sperm count and reducing damage to DNA
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