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It is important to mention that these O 2 levels do not represent the concentrations found inside human healthy and cancerous tissues and are followingly used to investigate the different therapeutic efficiency of the nanoparticle formulation in high and low O 2 atmospheres

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For preclinical tissue models, stronger evidence would require standardized injury models, blinded outcome assessment, histological confirmation, functional endpoints, and comparison against appropriate positive and negative controls

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Skin Repair : Improves skin integrity by promoting the synthesis of new extracellular matrix components while activating metalloproteinases (MMPs) that break down old or damaged proteins