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Perianal topical nitroglycerin, perianal topical diltiazem, and intramuscular (internal anal sphincter) injection of botulinum toxin are slightly more effective than placebo in healing anal fissures

Newer formulations that target multiple GLP-1 receptors are gaining widespread fervor online and may be even more effective for issues like weight loss, but we have limited data on their long-term risks and benefits

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This is why IGF-1 LR3 is typically studied in cycles of 4-8 weeks to maintain sensitivity and maximize the effectiveness of the protocol