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Effects of oral semaglutide on cardiovascular outcomes in individuals with type 2 diabetes and established atherosclerotic cardiovascular disease and/or chronic kidney disease: design and baseline characteristics of SOUL, a randomized trial

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It is synthesized primarily in the liver, kidneys, and brain

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Results from a phase 1 trial have supported further clinical evaluation with a dose-dependent WL up to 14.5% with AMG133 compared to 1.5% with placebo by day 85 [59]