Both oral and injectable versions reach the same therapeutic effect
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Pancreatitis (inflammation of the pancreas) Watch for: Bad stomach pain that does not go away (may spread to your back) Feeling sick and vomiting that does not stop Gallbladder problems GLP-1 medicines can slightly increase the risk of gallstones or gallbladder inflammation
Weight loss medications, including semaglutide, are not recommended during pregnancy
There are several reasons people might want to switch: Weight loss plateaus after a few months on semaglutide Gastrointestinal side effects like nausea or constipation that are not manageable Desire for better glucose control Personal goals (e.g., prefer faster weight loss progress ) In my practice, the most common reasons I recommend patients to switch medication is 1) they are having uncomfortable or unmanageable side effects from semaglutide including heart burn, nausea, constipation or 2) their weight loss starts to plateau before they reach their weight loss goals
Stimulation of Insulin Secretion (-cells) When GLP-1 RAs bind to receptors on pancreatic -cells, they activate adenylate cyclase (AC), increasing intracellular cyclic AMP (cAMP)