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It is not typically prescribed for use in individuals without diabetes unless there is a specific medical reason determined by a healthcare professional.

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doi:10.1056/nejm198806303182604 17Hunt A, Harrington D, Robinson S

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Research highlights the benefits of combining Metformin with GLP-1 treatments

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Orforglipron treatment was also associated with slower gastric emptying time and short-term weight loss, all of which are consistent with drug class effects , with up to 5.4 kg loss over 4 weeks in higher-dose cohorts

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