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Back to Journals Drug Design, Development and Therapy Volume 19 Semaglutide Alleviates Ovarian Oxidative Stress and Autophagy via the PI3K/AKT/mTOR Pathway in Mice with Polycystic Ovary Syndrome Authors Guo S, Li X, Liu M, Feng M, Wang X, Xue H , Zhang L Received 14 February 2025 Accepted for publication 5 May 2025 Published 23 May 2025 Volume 2025:19 Pages 42974310 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Muzammal Hussain Sili Guo, * Xiaohan Li, * Mei Liu, Meiqi Feng, Xi Wang, Haibo Xue, Lei Zhang Department of Endocrinology and Metabolism, The First School of Clinical Medicine, Binzhou Medical University Hospital, Binzhou Medicial University, Binzhou, Shandong, Peoples Republic of China *These authors contributed equally to this work Correspondence: Lei Zhang, Department of Endocrinology and Metabolism, The First School of Clinical Medicine, Binzhou Medical University Hospital, Binzhou Medical University, Binzhou, Shandong, Peoples Republic of China, Email [email protected] Haibo Xue, Department of Endocrinology and Metabolism, The First School of Clinical Medicine, Binzhou Medical University Hospital, Binzhou Medical University, Binzhou, Shandong, Peoples Republic of China, Email [email protected] Background: Polycystic ovary syndrome (PCOS) is a typical reproductive endocrine system disease with high incidence rate among childbearing age women

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She reports consultancy fees from AstraZeneca, Boehringer Ingelheim, Bayer, Eli Lilly, Novo Nordisk, Travere Therapeutics Inc, ProKidney and Alnylam

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A study published in JAMA found that participants who discontinued semaglutide gradually regained weight over time