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In the SCALE Obesity and Prediabetes trial (Pi-Sunyer et al., NEJM 2015), participants receiving Saxenda alongside lifestyle modification achieved mean weight loss of approximately 8% of initial body weight, compared with 2.6% in the placebo group

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Semaglutide is sold under three brand names, each with slightly different dosing profiles: Ozempic injectable, once-weekly, approved for type 2 diabetes and cardiovascular risk reduction Wegovy injectable, once-weekly, higher dose (up to 2.4 mg), approved for weight management Rybelsus oral tablet, taken daily, approved for type 2 diabetes All three share the same active ingredient and similar side-effect profiles, though Wegovy at higher doses tends to cause more frequent GI symptoms

TABLE 2 Candidate biomarkers of methylation in early diagnosis of colorectal, hepatocellular, gastric, pancreatic and esophageal cancers