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This matters because it argues against simple collagen accumulation

Bioavailability is the most critical factor in supplement success

Instead, it works downstream to protect cells from the damage that often results from metabolic activity

Data availability The RNA-seq data reported in this study were deposited in the NCBI Gene Expression Omnibus Database under accession number GSE297105

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Ethical statement Ethical approval of this study was granted by the Home Office of the United Kingdom (PP1309593) and the Animal Welfare and Ethical Review Body (AWERB) at the Animal and Plant Health Agency (APHA) and by the North of England Zoological Society (Chester Zoo) ethical review committee