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Personal or family history of auto-immune disease for instance, thyroid disease, vitiligo, type 1 diabetes, Sjogrens disease (dry mouth and other symptoms), Addisons disease
Smaller meals empty faster and cause less discomfort
Most patients do their B12 shots in-clinic since they're quick and cheap
If more methylcobalamin is needed, the body can produce it through the process of remethylation, using methylfolate again as the methyl donor
The honest default: run it alone