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The improved absorption might eliminate the irritation caused by unabsorbed ingredients
The reviewed report is for a 5mg sample
The strongest human evidence is topical, including the Leyden 2002 photoaging trial and a 2023 IRB-approved 21-woman topical NEEL gel study reporting an average 28% increase in skin collagen density at 3 months
But the mere presence of the enzyme does not guarantee its high activity
doi:10.1515/BC.2009.033 Mol Neurobiol