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A well-known collider bias, termed the obesity paradox, should be considered

p values below 0.05 were considered statistically significant

Fortunately, Mojsov was in very good company in the Merrifield laboratory, with colleagues such as Alexander R

This is not one of the harsh preservatives that cause reactions

Phase 2 Obesity Trial Jastreboff et al., New England Journal of Medicine (2023) Jastreboff and colleagues conducted a phase 2, double-blind, randomized, placebo-controlled trial of retatrutide in adults with obesity

This research offers further insight into this emerging safety signal, according to the study authors who noted in their Ophthalmology paper, Our novel, stratified analysis provides a more nuanced interpretation than previous pooled reviews, isolating a potential increased risk signal to observational data in the diabetes population only, a finding not corroborated by RCTs. These results are somewhat at odds with the narrative surrounding GLP-1 use and NAION risk that began in early 2024, but the researchers say they are confident in their methodology