To identify potential off-target substrates, we searched enriched motifs against the human proteome, using the enrichment score of the IL-1 motif (cleavage between Glu 18 and Asp 19) as the cutoff for predicted cleavage activity (Fig
The beginning of GPX2 and 30 years later
Conclusion As a starting point to inform deeper investigations into real-world variation and patient profiles for responsiveness to therapies, our research bridges the gap between clinical trials and GLP-1 use in the real world, where a broader, more diverse population is using GLP-1s in a variety of settings and personal contexts
Hepatology (Baltimore, Md.)
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Nature 481 , 385388 (2012)