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If you have MTHFR mutations, this conversion is less efficient, leading to higher homocysteine levels in your blood

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But far fewer know about IGFBP-3, its primary binding protein, which may hold the key to answering an increasingly important question: How much growth is too much, and when does it pose a cancer risk

Reference: Michiels C et al

(PubMed) Bernhard W, Poets CF, Franz AR