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A 2021 review published in Biomedicine & Pharmacotherapy explains that silymarin, the main active compound in milk thistle, can:25 Regulate the cell cycle, helping to ensure proper division and replication Induce apoptosis, or programmed cell death, by which the body can eliminate mutated cells (e.g., cancer cells) Regulate the body's immune response, increasing its ability to recognize and attack cancer cells Keep tumor cells from growing and spreading Inhibit angiogenesis, the process by which tumors create new blood vessels that increase their blood supply and help them grow The review specifically discusses silymarin's therapeutic potential for gastrointestinal cancer, but as another set of researchers note, silymarin has a pleiotropic effect, meaning it can act on multiple targets.26 Again, more research may be needed, but the current science suggests that milk thistle may have fairly broad complementary utility in cancer therapy

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Understanding the IGF-1 Splice Variant System The IGF-1 gene spans six exons and generates multiple distinct mRNA transcripts through alternative promoter usage and C-terminal alternative splicing

However, in murine models, exendin-4 demonstrates about 5,500-fold greater potency in improving glucose control, evidenced by the percentage fall in plasma glucose at 1 hour (87)