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High folic acid intake can also mask symptoms of vitamin B12 deficiency

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This is underscored by in vivo isotopic tracing studies in human lung cancers, which, despite revealing that circulating lactate can serve as a major respiratory fuel surpassing glucose in some tumors, simultaneously demonstrated that glucose, instead of glutamine, remains the primary substrate for carboxylation anaplerosis within tricarboxylic acid (TCA) cycle [29]