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When dieting, a B12 deficiency can occur due to the limitation of consumption of foods that are high in B12, such as red meat

First, our enteric nervous system (ENS), which is located throughout our gastrointestinal tract, helps control our same chemicals and cells as the brain to help us digest and to alert the brain when something is amiss (Ruder, 2017)

Oral B12 supplements have to pass through the gut, and absorption can be limited especially if you have digestive issues, take certain medications like metformin or antacids, or simply have low stomach acid

More striking is the gap in publicly available trial-grade data

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