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Cell studies show that BPA exposure directly causes a decrease in GLP-1 and insulin release through miR-338.[ref][ref] Related article: BPA, BPS, Genetics, and Detoxification Recap of your genes: FAQs: Do genetics affect how well semaglutide works

Goldenberg RM, Ahooja V, Clemens KK, Gilbert JD, Poddar M, Verma S

If you've been at the treatment for 6 months and have lost less than 5% of your starting weight, then switching to an alternative medication may be medically advisable after discussing it with your prescriber

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Frias JP et al

Exenatide acutely increases heart rate in parallel with augmented sympathetic nervous system activation in healthy overweight males