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Although it could be theoretically possible to enhance the reverse cholesterol effects of LXRs without targeting hepatic lipogenesis with the use of LXR-specific ligands since most of the hepatic responses are due to activation of LXR, this will be a difficult challenge as the ligand binding pocket in both isoforms has been shown to be nearly identical

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As GLP-1s like semaglutide and liraglutide explode in popularity, scientists are noticing a striking pattern: People taking these drugs tend to have lower rates of disease, such as brain disease, kidney disease, heart disease, liver disease, and even cancer