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Open research questions Important unanswered questions remain: the longterm cardiovascular implications of supplementrelated TMAO rises, optimal doseresponse in different age groups and sexes, and whether specific probiotics or conutrients can reduce gut conversion of carnitine to TMAO while preserving benefits

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Therapeutic interest: Initially studied for Alzheimers disease and other neurodegenerative conditions, Dihexa has since gained attention in the nootropic and performance communities for its potential role in learning, memory, and brain repair

173, 174 Contrary to mice that appear fit and viable even with very high tumor masses, humans generally develop advanced cachexia and die when tumor masses have already reached 0.1% of body weight

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