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All simulations were performed in the constant number, pressure, and temperature (NPT) ensemble, with water, lipids, and drug molecules coupled separately to a heat bath with temperatures in the range of 37227 C using a time constant T = 0.1 ps in combination with the velocity rescaling algorithm 24

Biochemistry 52, 76897701

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Stickels RR, Murray E, Kumar P, et al

Global cancer transitions according to the Human Development Index (20082030): a population-based study