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Increased trimethylamine N-oxide contributes to metabolic dysfunction in a rat model of PCOS and decreases mitochondrial function
Until an oral formulation is approved, gastric-emptying-mediated DDIs remain confined to co-administered oral drugs rather than retatrutide itself
They are difficult for the body to synthesize or unable to synthesize at all
By activating PPARs, it improves lipid metabolism and energy homeostasis, offering therapeutic potential for type II diabetes and obesity (12, 20)