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[35], Bid only becomes active and translocates to the mitochondria after being cleaved by caspase 8 and transformed into truncated Bid (tBid)

Eur J Drug Metab Pharmacokinet 41:839844

These TAMs, once recruited by the CCL2 secreted by resistant cancer cells, were polarized into an M2 phenotype, which is known to promote tumor progression and further enhance resistance to paclitaxel