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Indeed, the actions of relaxin-2 have also been observed in males and non-pregnant women [3, 4]
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Acknowledgements This work was supported by research grants from the National Key Research and Development Program of China (2016YFA0100501), the Chinese National 973 Program (2012CB517502), the National Natural Sciences Foundation of China (81400798, 81400767, 81401142, 81270858, and 81570692), and the Beijing Natural Sciences Foundation of China (7163233)
Theoretical interactions with other OCTN substrates are possible but not clinically documented.[23] Clinical Significance: ALC has a favorable drug interaction profile with minimal pharmacokinetic interactions
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Thus these changes must come from some other effect of chromosome 21 trisomy
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