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Safety and Side Effects (What People Should Know) The most common reason people stop semaglutide is stomach-related side effects, such as: nausea vomiting diarrhea constipation In SELECT, more people stopped semaglutide than placebo due to these effects

The Evolving Role of Weight Loss Pharmacotherapy

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Medications such as semaglutide should be used as a last resort if diet and lifestyle changes have not been implemented

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Physicians may choose lower doses that avoid the side effects associated with the higher doses needed for significant weight loss, potentially also lowering costs for patients, Drucker said