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This hyper-proliferative state drains the body's metabolic energy and drives the profound fatigue seen in these conditions

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Both transporters have been shown to efflux folates from intestinal enterocytes and, as such, can compete with the activity of PCFT in folate uptake

Proper storage slows these processes and maintains potency throughout the usable life of the vial

No specific diet is required, but certain dietary strategies dramatically improve outcomes

Card Fail Rev 3:711 Usman MS, Siddiqi TJ, Memon MM, Khan MS, Rawasia WF, Talha Ayub M, Sreenivasan J, Golzar Y (2018) Sodium-glucose co-transporter 2 inhibitors and cardiovascular outcomes: a systematic review and meta-analysis