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[1] [3] Secondary carnitine deficiencies may happen as the result of certain disorders, such as chronic kidney failure, or under conditions that reduce carnitine absorption or increase its excretion, such as the use of antibiotics, malnutrition, and poor absorption following digestion

This mechanistic distinction is one reason these compounds are sometimes studied together in multi-compound laboratory research designs (each acts on a different pathway, so each provides an independent variable for the research design)

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However, endothelial signaling data from controlled laboratory systems should not be converted into clinical cardiovascular claims

These investigations revealed that metabolic anomalies could offer a fresh perspective on renal diseases