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1 Among those who stayed on the pill and reached the maintenance dose, the average weight loss was 16.6%

Drugs Exp Clin Res 1993;19:213-7

Administration: Taken as a once-weekly injection under the skin

Staying hydrated and maintaining steady nutrient intake can shorten this period

For example, investigators found that orexigenic effects of systemically administered ghrelin (also known as the hunger hormone) were abolished in CB 1 receptor knockout mice 40 , and pharmacological blockade of the CB 1 receptor, via rimonabant administration, attenuated ghrelin-induced activation of the mesolimbic dopamine system a key pathway involved in reward processing 41

The functional role of the T1R family of receptors in sweet taste and feeding