For research built around the core three mechanisms, the GLOW blend is the established, convenient single-vial formulation
However, theyre also divided into groups
37 Giri TK, Newton D, Chaudhary O, Deych E, Napoli N, Villareal R, Diemer K, Milligan PE, Gage FB
Dose-by-dose weight loss in Phase 2 (NEJM) Phase 2 NEJM weight loss by dose, 24 and 48 weeks Dose 1 mg 24 weeks -7.2% 48 weeks -8.7% Dose 4 mg 24 weeks -12.9% 48 weeks -17.5% Dose 8 mg 24 weeks -15.7% 48 weeks -22.8% Dose 12 mg 24 weeks -17.5% 48 weeks -24.2% Dose Placebo 24 weeks -1.6% 48 weeks -2.1% Source: Jastreboff et al., NEJM 2023
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Many patients report feeling better when switching from T4-only thyroid medication to NDT (6) and this likely has to do with the addition of the T3 in this medication