While preclinical human studies support its safety and receptor selectivity, caution remains essential due to its systemic effects on metabolism
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47,49,50 Medications that diminish platelet function should generally be avoided in patients with hypermobile EDS who have easy bruising
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One way to circumvent the problem of lack of cost savings is to better target reimbursement by stratifying subgroups of obese patients into those expected to benefit the most versus those for whom the return isnt as good
It is important to note that randomized trials typically involve a highly selective group of individuals who do not accurately reflect the general population with T2DM