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It was determined that the +4 was the dominant charge state for each of the analytes monitored: Retatrutide 4731.3 Da= 1184 m/z Semaglutide 4113.6 Da= 1029 m/z Tirzepatide 4813.5 Da= 1204 m/z The charge state was determined by the following equation: The same method used for the LC-UV analysis was able to be applied to MS to achieve better sensitivity

SMPG, self-monitored plasma glucose

Results of STEP 1-4 were published this spring: STEP 1 tested a 2.4 mg weekly injection of semaglutide plus lifestyle intervention in 1,961 patients without diabetes

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