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In obesity-related HFpEF, where inflammation and metabolic dysfunction sit at the center of the disease, semaglutide was a natural fit. So, while weight loss across the board was anticipated (about 8% to 9% of body weight compared to placebo), the results this team found intriguing were semaglutides stratum-dependent ability to reduce frailty burden (strata = less frail, more frail, most frail)
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Significant weight loss: On average, patients can lose approximately 50-75% of their excess weight within 12-18 months of sleeve surgery
Smaller water volumes give a more concentrated solution (fewer units per dose)
