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At three-year follow-up, participants in the intervention arm showed lower depression severity and higher self-efficacy than controls [109]
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Science 256 (5054), 1845
Weight loss was significant in outcome trials, ranging from a 0.6 kg reduction at 12 weeks in the ELIXA trial to a 4.3 kg reduction at 2 years with injectable semaglutide in the SUSTAIN-6 trial
Although prolonged GSH depletion induced triglyceride depletion and reduced epididymal adipose tissue in mice, it induced a sex-dependent requirement of NRF2 expression in the liver
Similar to the first trial, the placebo group only experienced about five less
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