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Together with the ability of metformin to improve intestinal barrier integrity and strengthen it by increasing intestinal expression of TJ proteins, these data suggest that metformin also indirectly reduces insulin resistance through modulating GM composition, SCFA levels, and intestinal barrier integrity

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2002;69Suppl 1:SI53-8

Versus biomimetic cosmetic peptides (matrixyl, argireline, acetyl hexapeptide): these peptides are protein fragments with targeted activity (calcium neurotransmission modulation for argireline, matrix stimulation for matrixyl)

Patten DA, Germain M, Kelly MA, Slack RS

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