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| Weeks | Dose | Purpose | |---|---|---| | 1 to 4 | 0.25 mg once weekly | Tolerability induction | | 5 to 8 | 0.5 mg once weekly | Minimum effective therapeutic dose | | 9 to 12 (optional) | 1.0 mg once weekly | Enhanced glycemic control | | 13 to 16 (optional) | 1.7 mg once weekly | Bridge to maximum dose | | 17+ (optional) | 2.0 mg once weekly | Maximum approved dose for T2D | Dose advancement is not mandatory at every step
High levels are associated with heart disease, hardening of the arteries, diabetes, and colon cancer
By targeting glucagon, retatrutide may help the body access and use stored energy more efficiently, while the targeted GLP-1 and GIP hormones help support fullness, appetite control, and blood sugar regulation
Over time, data from tools like Libre sensors may even be used to help evaluate the effectiveness of GLP-1 drugs
PMID 27562997
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