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In chemotherapy-sensitive patients, Keap1 (Kelch-like ECH-associated protein 1) binds to NRF2 and mediates NRF2 ubiquitination via the Cul3-E3 ligase complex, promoting its degradation and maintaining NRF2 at low levels [32]
AM / PM Recommended Amount: A few drops
Typical ALA dosing ranges from 300-600mg daily, often split into multiple doses due to its relatively short half-life
(2015) 5:e528
However, the longer a therapy continues, the higher and higher the likelihood of improvement regardless of circumstance, especially in an illness with as much natural variability as ME/CFS
(PubMed) Riccioni G, D'Orazio N, Palumbo N, et al
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