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32,43 Moreover, because of the heterogeneous nature of tumors, there are considerable variations in NADPH-related processes in different tumors, for example, the main pathways of glutamine metabolism in the context of PDAC are different from the previous prevailing view as informed by studies of other cancers, 159,192 indicating the need for careful analyses of individual characteristics among cancers for establishing individualized precision therapy
Much of the research on ROS production and redox regulation in the 1970s and 1980s was focused on the chloroplast, and the paper by Foyer and Halliwell (1976) shone a light firmly on ascorbate and glutathione specifically within this compartment
Presented for research literature review only LeBlanc GA et al
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2 GPX family and oxidative stress 2.1 GPX1 Glutathione peroxidase 1 (GPX1) was first identified in 1957 as a red blood cell enzyme that protects hemoglobin from oxidative stress ( 2 O 2 and soluble low-molecular hydroperoxides, but not with more complex lipid hydroperoxides
Phagocytosis of phenylhydrazine oxidized and G-6-PD-deficient red blood cells: the role of cell-bound immunoglobulins
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