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Senolytic FOXO4-DRI can inhibit FOXO4 binding by disrupting the p53-FOXO4 interaction and selectively cause apoptosis via p53 nuclear exclusion in senescent cells and aging mouse models, which may be a promising approach for preventing senescence 11

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Suppressed fibroblast function, decreased collagen synthesis and increased MMPs lead to a reduction in extracellular matrix Subsequent studies focusing on estrogens mechanism of action have largely employed ovariectomised (OVX) rodents