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The immune-inflamed subtype exhibited a less-than-ideal response to various drugs, with a secondary loss of response
However, metformin administration failed to rescue paw withdrawal thresholds or pain sensitivity in Nrf2 KO mice, unlike the protective effects observed in MIA-induced WT OA mice (Fig
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Although rosavin displays lower oral bioavailability, it may contribute synergistically through peripheral stress-modulating and MAO-inhibitory actions
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It can be taken during meals, before and after training
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