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Open question Whether the same mechanisms are clinically meaningful in humans is not yet established
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Vaessen N, Heutink P, Janssen JA, Witteman JCM, Testers L, Hofman A, Lamberts SWJ, Oostra BA, Pols HAP, Van Duijn CM
The groups that received the riboflavin-fortified salt had lower rates of esophageal cancer.[ref] Inflammatory Bowel Disease (IBD): In patients with Crohns disease, riboflavin (100mg/day) decreased inflammatory markers significantly in three weeks.[ref] Related article: IBD and Genetic Connections Inflammation: A randomized, placebo-controlled trial of supplemental riboflavin found that it reduced inflammation based on a lower CRP level.[ref] Related article : Inflammation and chronic disease Gut microbiome interactions with riboflavin: Certain gut microbes can produce riboflavin, part of which is then absorbed into the body
For these reasons, we prefer injecting B12 into fat
It is what the evidence actually supports, and where a nutrient injection still fits now that GLP-1 agonists exist
