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The EMA PRAC 2024 review found no causal link between licensed GLP-1 receptor agonists and suicidal ideation or self-harm, but this conclusion cannot be directly applied to retatrutide, which has additional glucagon receptor activity and lacks its own long-term safety data
However, in the presence of 20% human plasma, a 100-fold rightward curve shift was observed for the lipidated compounds, but not the conjugates and the GLP-1 analogue, indicating that MK-801 and inactive MK-801 do not associate strongly with HSA (Fig
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doi: 10.1111/nmo.12378 114 JiangHLingZZhangYMaoHMaZYinYet al
doi:10.1177/2042018821997320
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