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Tesamorelin is FDA approved for reducing excess abdominal fat in adults with HIV-associated lipodystrophy and is not approved as a general weight-loss or longevity treatment

The thigh, specifically the front and outer portions of the upper leg, provides another option

BPC-157 would still require a full New Drug Application (NDA) supported by adequate human clinical trials to achieve formal FDA approval

HA may contribute by reducing collagen degradation, scavenging reactive oxygen species, and inhibiting matrix metalloproteinases

Finally there is a substantial body of cell-culture observation on fibroblast behavior, including proliferation, migration and matrix deposition, with a smaller keratinocyte literature alongside it

Less senescence in supporting cells supports normal sperm production and maturation