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Immune, neurological, gastrointestinal, and mitochondrial comprehensive testing can help map out which systems are most affected and guide the sequence of intervention

Kleinman HK, Sosne G

Rather than activating DCs, broccoli-derived EVs (BrDEVs) appear to induce a tolerogenic DC phenotype via adenosine monophosphate-activated protein kinase (AMPK) pathway activation

Downstream signaling involves PI3K/AKT, MAPK/ERK, and PLC- pathways, which are well-characterized drivers of synaptogenesis, dendritic spine maturation, and neuronal survival