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This timeframe can be longer or shorter, depending on the number of areas being treated and the specific requirements of each case
The decrease in reaction rate is caused by the decrease in [SAM] and the increase in [SAH], which inhibits DNMT
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In conclusion, while the association between metformin and the incidence of certain cancers remains a subject of debate, metformin exhibits significant protective effects against multiple types of tumors, demonstrating efficacy in inhibiting tumor cell proliferation and progression, reducing cancer risk, and improving cancer-related outcomes [107]
47 It is important to note that the mucositis associated with LDMTX use is less severe than the widespread, acute toxic reactions typically observed with high-dose MTX treatment, 7 even though multiple ulcers are commonly reported
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