With clinically meaningful weight loss and cardiovascular outcomes in patients with type 2 diabetes, GLP-1RAs were further assessed in patients with overweight or obesity without type 2 diabetes in the 2021 STEP-1 trial and 2022 SURMOUNT-1 trial
Conclusion This review has outlined the clinical rationale for combining pharmacological therapy, particularly GLP-1 RAs like semaglutide, with personalised dietary strategies in the treatment of obesity
Lancet 397(10271):293304
Lambert says purity refers to the presence of endotoxins or exogenous materials in a drug that could cause harm
The results suggest its superiority in improving glycemic control and promoting weight loss compared to existing treatments, but as always, further research is warranted
Wegovy is indicated for people ages 12 years and older who have: A BMI of 30 kg/m 2 or higher A BMI of 27 kg/m 2 to 29.9 kg/m 2 and at least one weight-related comorbidity , such as high blood pressure, type 2 diabetes, or obstructive sleep apnea Wegovy is also indicated to reduce the risk of major cardiovascular events , such as heart attack or stroke, in people who have obesity or overweight