In the first, it undergoes oxidation within the TCA cycle [often called the Szent-GyrgyiKrebs cycle, acknowledging the Nobel Prize (1937) winning contributions of Albert Szent-Gyrgyi in identifying the fumarate, malate and oxaloacetate forming reactions towards the end of the cycle, and those of Hans Adolf Krebs, Nobel Prize (1953), for elucidating the details of the overall cycle], ultimately being converted to pyruvate and lactate in the cytosol through a metabolic process known as glutaminolysis (represented by blue arrows) (Albert Szent-Gyrgyi FactsNobelPrize.org n.d
The research peptide route operates in a regulatory grey area with associated quality and legal risks that each individual must evaluate for themselves
It produces inflammatory cytokines, disrupts insulin signaling, and increases cardiovascular disease risk
Oxidative Med Cell Longev 2013:112 Cady J, Koval ED, Benitez BA, Zaidman C, Jockel-Balsarotti J, Allred P, Baloh RH, Ravits J, Simpson E, Appel SH, Pestronk A, Goate AM, Miller TM, Cruchaga C, Harms MB (2014 Apr) TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis
PMID 31447084
your healthcare provider may need to reduce doses of these medications when starting tirzepatide